Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation
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چکیده
منابع مشابه
Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation.
Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that occurs following prolonged controlled mechanical ventilation (MV). The presence of VIDD impedes recovery from respiratory failure. However, the pathophysiological mechanisms accounting for VIDD are still not fully understood. Here, we show in human subjects and a mouse model of VIDD that MV is assoc...
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Respiratory muscle weakness is considered to be a factor in the inability to wean from mechanical ventilation. To assess this possibility, the present study examined the mechanical behavior of the diaphragm by measuring the change in transdiaphragmatic pressure (delta Pdi) during weaning. Nine "T-piece" weanings were carried out in seven patients with prior weaning failure and were terminated w...
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Mechanical ventilation (MV) is associated with diaphragmatic oxidative stress that contributes to both diaphragmatic atrophy and contractile dysfunction. However, the pathways responsible for oxidant production in the diaphragm during MV remain unknown. To address this issue, we tested the hypothesis that diaphragmatic nitric oxide synthase (NOS) activity is elevated during MV, resulting in nit...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2016
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1609707113